PharmaMar has a pipeline of drug candidates and a robust R&D oncology program. Its commitment to patients and to research has made it one of the world leaders in the discovery of antitumor drugs of marine origin. It is a company that seeks innovative products to provide healthcare professionals with new tools to treat cancer. Headquartered in Madrid, PharmaMar is a biopharmaceutical company, focused on oncology and committed to research and development which takes its inspiration from the sea to discover molecules with antitumor activity. ![]() This press release does not constitute an offer to sell or the solicitation of an offer to buy securities, and shall not constitute an offer, solicitation or sale in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of that jurisdiction. With this new agreement, lurbinectedin could soon reach Latin American patients with metastatic Small Cell Lung Cancer.' Outside of the US, lurbinectedin is available to patients in selected countries via named Patient Access Programs.Īccording to Luis Mora, General Manager of PharmaMar's Oncology Business Unit, 'This is our second commercial agreement with ADIUM, following the one signed a year ago with them for Yondelis. PharmaMar and Adium agreed to submit regulatory filings in several Latin America countries in the coming months. Lurbinectedin regulatory review process in certain countries falls under the ' Project Orbis' initiative which allows collaboration between the FDA and selected international regulators. Additional marketing authorization applications have been submitted to health agencies in Australia, Canada, Switzerland, Israel, and others under accelerated approval pathways. Lurbinectedin is commercialized by PharmaMar's partner Jazz Pharmaceuticals in the United States since its approval by FDA ( Food and Drug Administration) for the treatment of metastatic Small Cell Lung Cancer on June 15th, 2020. PharmaMar will retain exclusive production rights and will sell the finished product to Adium for its clinical and commercial use. PharmaMar will also be eligible to receive additional remunerations of up to EUR6.5 million upon achieving regulatory and sales milestones. Under the terms of the agreement, PharmaMar will receive an upfront payment of EUR2 million upon signing and providing the US dossier of lurbinectedin to Adium. of Montevideo, Uruguay, to commercialize the anticancer drug Zepzelca (lurbinectedin) in Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Curacao, Dominican Republic, Ecuador, El Salvador, Guatemala, Honduras, Jamaica, Mexico, Nicaragua, Panama, Paraguay, Peru, Trinidad and Tobago, Uruguay and Venezuela. (MSE: PHM) has announced today a licensing agreement with Adium Pharma S.A. QUE CONTENGAN PRODUCTOS DE LAS PARTIDAS 2930 A 2932, SIN PRODUCTOS DE LAS SUBPARTIDAS 3004901 A 3004904. MEDICAMENTOS (EXCEPTO LOS PRODUCTOS DE LAS PARTIDAS 3002, 3005 O 3006) CONSTITUIDOS POR PRODUCTOS MEZCLADOS O SIN MEZCLAR, PR ![]() ![]() QUE CONTENGAN PRODUCTOS DE LAS PARTIDAS 2924 A 2926, SIN PRODUCTOS DE LAS SUBPARTIDAS 3004901 A 3004903. LOS DEMAS, QUE CONTENGAN VITAMINAS U OTROS PRODUCTOS DE LA PARTIDA 2936. MEDICAMENTOS (EXCEPTO LOS PRODUCTOS DE LAS PARTIDAS 3002, 3005 O 3006) CONSTITUIDOS POR PRODUCTOS MEZCLADOS O SIN MEZCLAR, PREPARADOSĭ-PANTOTENATO DE CALCIO VITAMINA D3 (COLECALCIFEROL). QUE CONTENGAN PRODUCTOS DE LA PARTIDA 2933, SIN PRODUCTOS DE LAS SUBPARTIDAS 3004901 A 3004905. MEDICAMENTOS (EXCEPTO LOS PRODUCTOS DE LAS PARTIDAS 3002, 3005 O 3006) CONSTITUIDOS POR PRODUCTOS MEZCLADOS O SIN MEZCLAR, PREPARADOS PARA USOS TERAPEUTICOS O PROFILACTICOS, DOSIFICADOS (INCLUIDOS LOS ADMINISTRADOS POR VIA TRAN
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Upon joining the show, she became “the first Korean drag queen to be featured on American national television” and her mother didn’t know she did drag until the series aired on March 7th, 2016. Kim Chi competed with eleven other queens on season eight of RuPaul’s Drag Race. ![]() According to Trixie, they shared makeup, and were also romantically involved– but are still good friends. She still did drag, though it wasn’t her main career, and her inspiration was performance artist Leigh Bowery.īefore Drag Race, she knew Trixie Mattel and helped her book one of her first gigs in Chicago, as Trixie had trouble finding work in her native Milwaukee. She studied graphic design, as well as sculpture, fashion design, and painting, before working as an art director. Although her original drag name was completely different, it became “Kim Chi” after the Korean pickled cabbage dish. As she grew older, she began dressing in drag for Halloween. Good taste!) When she was little, she would dress up in her mother’s clothes. (Around this time, she also said that she had a crush on Fred from the Scooby-Doo cartoon. In Michigan, she was known as “Eric Shin”– after Prince Eric in The Little Mermaid, her favorite movie at the time. She spent her childhood in South Korea before moving to a small town in Michigan. Kim Chi was born Sang-Young Shin on August 8th, 1987 (Leo) in Chicago, Illinois to Korean parents. She’s also one of my personal favorites– I follow her on Twitter and Instagram, and she’s hilarious! Known for her bold, over-the-top makeup, shady Tweets (fans call her “Shade Chi” on occasion) and self-depreciating humor, she definitely knows how to make an impression. With 1.9 million Instagram followers, a WOWIE Award-nominated makeup line, and a coveted spot in the Werq the World tour, she’s one of the franchise’s superstars. Kim Chi is one of the most popular RuPaul’s Drag Race queens of all time. It became “Sad Music Sunday” but I just listened to a slow violin version of “The Thong Song.” (Just kidding!) I was about to swear off attraction for good, then…I started my period! (Of course….)īut I also made sure to thoroughly edit this post– which I started a week ago. An old Turkish proverb says, “A man without a belly is like a house without a balcony.” But am I wrong…? This is the spiral of stupidity I found myself in.) I usually don’t care what others “might” think of the men I like, so such a thought was as out-of-place as a laser-pointer at a funeral, gum stuck to a gravestone, sky burial via shooting the deceased from a cannonball, ashes in a Shrek shampoo bottle, etc. Does anything really go? Is it considered “problematic” these days? Would I be “cancelled” for liking a husky man? I know they were considered handsome at some point in history. Societally, I don’t know what’s considered right or wrong. ![]() (I prefer men who are bigger– or at least have a potbelly. Yesterday I nearly burst into tears because I was paranoid that some men I liked did something bad, (Gregory Peck, James Garner, and Simon Oakland…I saw a thread on how terrible Old Hollywood men were, and I worried that they had dark secrets.) and I was also worried that I was gonna get roasted (I don’t know how– I’m pretty quiet) for the type of men I am attracted to. (Note: I will be using female pronouns for ease, going in and out of Kim Chi’s drag persona.) I celebrate all things cute, fun, weird, and exotic.” –Kim Chi on her drag persona “Kim Chi is a live-action anime character whose fashion aesthetic could be described as ‘bionic doily.’ I imagine my aura to be an array of ultraviolet colors that spews glitter. ![]() From November through February, sites are available on a first-come, first-served basis. Reservations can be made through the "ReserveAmerica" website from March through October. There are no sewer hookups at the campsites however, a dump station is available. A campground store reopened in late 2010 (after being closed following storm damage from Hurricanes Ivan and Dennis in 20, respectively). Central restrooms and showers are available. The environment is characterized by sand scrub oaks, small brackish ponds, and a remnant pine forest on a barrier island between Pensacola Bay and the Gulf of Mexico. Roads are paved throughout the campground, as well as each campsite. In Florida, the Pickens Campground is a developed one and provides water and electrical hookups for recreational vehicles and tents. Campground fees are posted at the " Fees and Reservations" website. Primitive camping is also permitted in designated areas. Two developed campgrounds are located in the National Seashore.
![]() Many security, privacy, and performance features.□ For everyone who can’t install Ableton Live Suite on Mac and to overcome applications errors you should first Clean your Mac Before you Install it. □ Clean first your mac before installing Ableton Live Suite ![]() ![]() ▶️ Open the link by using Safari or Chrome : To avoid errors like system compatibility report or error code 195 or quit unexpectedly mac applications, INCOMPATIBLE M1 or M2, If you have Chip M1 or M2 use the following instructions to Install Adobe After Effects on Chip M1 or M2 and more follow those instructions. ▶️ Open the link by using Chrome : Download Now or Download Now To avoid errors like system compatibility report or error code 195 or quit unexpectedly of adobe products & more follow those instructions.Īttention □ ! Before you start install process you should first install Adobe Flash Player 2023 ✅ Latest version to do not face any future issues while using Ableton Live Suite also to accelerate rendering. This program has a lot to say about music mastering and you can create and edit your music like a powerful virtual studio. In this program, with the availability of a wide range of instruments, effects, sounds, loops and pieces of songs, your hands are open to composing. One of the most important features of music composition software is the richness of its library of sounds and musical instruments. Any change in any part of the stages of music creation is synced automatically and live in other parts, so it is possible to see the applied changes at the same time as editing the music in each stage. This program provides a wide range of features in a simple and beautiful graphic environment. Ableton Live Suite 11.2.11 Cracked Full Version For Windows/macOS DescriptionĪbleton Live Suite is a complete music creation station. List of Improvements and Video Exampleġ440p Graphics Mod With Normal Open World Distanceġ440p resolution and increased graphical quality. List of Improvements and Video Exampleġ080p+MB Graphics Mod With High Open World Distanceġ080p resolution and graphical quality with farther open world draw distance and added motion blur. List of Improvements and Video Exampleġ080p Graphics Mod With High Open World Distanceġ080p resolution and increased graphical quality with farther open world draw distance. List of Improvements and Video Exampleġ080p+MB Graphics Mod With Normal Open World Distanceġ080p resolution and increased graphical quality with added motion blur. ![]() List of Improvements and Video Exampleġ080p Graphics Mod With Normal Open World Distanceġ080p resolution and increased graphical quality. List of Improvements and Video Exampleħ20p+MB Graphics Mod With High Open World Distanceħ20p resolution and graphical quality with farther open world draw distance and added motion blur. List of Improvements and Video Exampleħ20p Graphics Mod With High Open World Distanceħ20p resolution and increased graphical quality with farther open world draw distance. List of Improvements and Video Exampleħ20p+MB Graphics Mod With Normal Open World Distanceħ20p resolution and increased graphical quality with added motion blur. Essentially unlocked fps.ħ20p Graphics Mod With Normal Open World Distanceħ20p resolution and increased graphical quality. Unlocks the framerate to run at 240 FPS during gameplay, the open world, and cutscenes. Unlocks the framerate to run at 60 FPS during gameplay, the open world, and cutscenes. Might break other blur effects.Ĭhanges target frame-rate from 30fps to 60fps. Increases the detail on far away texturesīypasses the issue with game intro and credits video(s) by replacing it with a 'dummy' 1 second video file.ĭisables the game's automatic adjustment of resolution.ĭisables Bloom effect. A workaround for it flickering on the Vulkan API Required for playing this titleĭisables the game's Flashlight Lens Flare. Makes the game run full speed 30 FPS, including distant 30 FPS NPC animations (NPC animations are normally 15 FPS)ĭisables the game's automatic adjustment of resolution. Makes the game run full speed dynamic 60 FPS, including distant NPC animations (Very demanding on CPU/GPU) Makes the game run full speed dynamic 60 FPS Helps to reduce stutters caused by dynamic resolution changes Makes the game render at 2160p resolutionĭisables dynamic resolution swapping. Unlocks all unlockables and Pit Stop items Enable 'Stretch to Window' in Yuzu's graphics settings for this to work properly.ĭisabled the on screen interaction cursor iconįorces the game to always run at 1920x1080ġ.0.7 1.0.9 1.0.10 1.0.11 1.0.12 1.0.13 1.0.14 1.0.15 Makes the game render with a 4:3 aspect ratio for CRT displays. Enable 'Stretch to Window' in Yuzu's graphics settings for this to work properly. Makes the game render with a Hor+ 21:9 aspect ratio for Ultrawide displays. ![]() Makes the game render with a 16:10 aspect ratio. Victoria4dx, theboy181, Claude von Riegan ![]() Makes the game render with a Hor+ 32:9 aspect ratio for Super Ultrawide displays. For any issues with this program, contact its developer through the mod downloader's GitHub repository. If you're looking for an automated process to install these mods, you can try the Yuzu Mod Downloader by amakvana.ĭISCLAIMER: This is not an official mod downloader from yuzu team, so we cannot guarantee support for it in our Discord server or support forums. For info on how to use mods, refer to the Game Modding page. Something fresh and colorful will help motivate you to keep your space clean and neat, so maybe next year’s spring cleaning will be a quick and simple task.
Writing rarely leads to wealth or celebrity, and even if it does, the act of writing and sharing that writing with others needs to be the most important part. Finally, writing needs to be its own reward.You also must be careful that you don’t overdo research or use it as a substitute for the actual writing. Sometimes, these can be the most difficult parts to eliminate or see the problems with due to your affection toward them. One of those pieces of advice is to murder your darlings in other words, you have to cut the parts of your book that you love the most if they are not working toward the overall cohesion of the story. King also reiterates advice many writers may have heard often.A writer must find her own style and stories within. King argues that fear and a lack of confidence lead to bad writing. One of a writer’s greatest strengths is who they are and what they uniquely have to offer.That will allow you to come back to it and appreciate it with a fresh eye. However, once the novel is finished, it should be set aside for several weeks. ![]() Furthermore, any novel of any length is written in the same way: one word at a time. He suggests three months, but even if you can’t manage a first draft quite this quickly due to other obligations, it’s better to put the pressure on yourself with a deadline than to tinker endlessly with the first few chapters of your book. ![]() King says the first draft should be completed in a short time.
![]() Specifically designed so that you can easily transition to LEDs without necessarily revamping your current lighting setup. Above all, LED Panel lights are the great application for hotels, offices, balcony, and many more. Whether you want to give that savvy look to your office ensure excellent lighting for your school or even light up your home (kitchen, common rooms / living space and/or study) and achieve that luxurious feel your friends will surely envy, our LED panel lights are the perfect cost-effective, eco-friendly and energy efficient solution for you. And, contain no harmful gasses or toxins like its fluorescent counterparts. The housing not only ensures protection from adverse environmental conditions but also serves as a heat sink to minimize thermal output keeping the area cool.Īs with all LED products, LED panel lights have a long lifespan (42 times longer than incandescent bulbs). ![]() Built within a sturdy case the array of LED diodes emit light in unison as they are concentrated And bounced through layers of material which enhance and diffuse the light in uniformity. Available in different sizes, shapes and color temperatures the LED panel is your “go to” lighting solution for that classy feel at a low price. LED Panels Light Square 6W Daylightare the general lighting alternative for those who want to incorporate cost-efficiency, brighter lighting, and elegant design. ![]() They also represent a complementary approach to existing circuits- and systems-based interrogation of nervous system function, opening the door for deeper and more targeted analysis in the future.Ĭitation: Betzel RF, Wood KC, Angeloni C, Neimark Geffen M, Bassett DS (2019) Stability of spontaneous, correlated activity in mouse auditory cortex. These findings represent a conceptual bridge linking network analyses of macroscale and cellular-level neuroimaging data. Despite this, a small subset of neurons maintain their connections to one another and preserve their modular organization across time, forming a stable temporal core surrounded by a flexible periphery. However, we show that connection weights and modular structure are also variable over time, changing on a timescale of days and adopting novel network configurations. We show that these networks exhibit spatially constrained, hierarchical modular structure, which may facilitate specialized information processing. Here, we reconstruct networks from calcium imaging data recorded in mouse primary auditory cortex. Still, little is known about the organization of these networks at the cellular scale and their stability over time. Neurons coordinate their activity with one another, forming networks that help support adaptive, flexible behavior. The methods are flexible and easily extended to additional datasets, opening the possibility of studying cellular level network organization of neural systems and how that organization is modulated by stimuli or altered in models of disease. Our work indicates a framework for studying spontaneous activity measured by two-photon calcium imaging using computational methods and graphical models from network science. Finally, we show that a small fraction of cells maintain strongly-correlated activity over multiple days, forming a stable temporal core surrounded by a fluctuating and variable periphery. We also show that, on average, network architecture becomes increasingly dissimilar over time, with similarity decaying monotonically with the distance (in time) between sessions. We show that the networks exhibit modular structure across multiple topological scales and that these multi-scale modules unfold as part of a hierarchy. We reconstruct functional networks in which cells are linked to one another by edges weighted according to the correlation of their fluorescence traces. Here, we used two-photon calcium imaging to record spontaneous activity from the same set of cells in mouse auditory cortex over the course of several weeks. The resulting network can be analyzed using mathematical tools from network science and graph theory to quantify the system’s topological organization and to better understand its function. Neural systems can be modeled as complex networks in which neural elements are represented as nodes linked to one another through structural or functional connections. Santa Fe Institute, Santa Fa, New Mexico, United States of America * E-mail: of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America,ĭepartment of Electrical and Systems Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America,ĭepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America,ĭepartment of Physics & Astronomy, College of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America,ĭepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, ![]() Navigating through your financial realm is a delight, with a wealth of information laid out intuitively. The sheer elegance of the app's interface mirrors Apple's commitment to simplicity, ensuring that even complex financial data is presented in a user-friendly manner. Amidst a sea of plastic, what truly sets them apart is the seamless blend of accessible information and effortless usability. In the realm of credit cards, where appearances often blur into similarity, Apple's Card and Wallet applications emerge as a beacon of distinction. See /wallet for details.Ħ Only available with select partners and locations, and requires eligible device and OS version. Apple Card is subject to credit approval, available only for qualifying applicants in the United States, and issued by Goldman Sachs Bank USA, Salt Lake City Branch.Ĥ Apple Cash services are provided by Green Dot Bank, Member FDIC. See /apple-cash for more information.ĥ Available for use only in select states at select TSA checkpoints. ![]() To access and use all Apple Card features and products available only to Apple Card users, you must add Apple Card to Wallet on an iPhone or iPad that supports and has the latest version of iOS or iPadOS. ģ Accepting an Apple Card after your application is approved will result in a hard inquiry, which may impact your credit score. To use Apple Pay Later, you must have an iPhone or iPad updated to the latest version of iOS or iPadOS. CA loans made or arranged pursuant to a California Financing Law license. Loans made by Apple Financing LLC, NMLS #2154940. To learn more about all of the ways Wallet app replaces your physical wallet, visit ġ Your bank may charge you fees if your debit card account contains insufficient funds to make loan repayments.Ģ Subject to eligibility and approval. 6 Unlock doors with just a tap of your iPhone or Apple Watch, and securely share keys in Wallet through messaging apps, including Messages, Mail, and more.Īdd your favorite coffee shop, drugstore, or retail rewards cards to Wallet, and next time you’re at checkout, just tap and pay to receive and redeem rewards. ![]() Store keys to your car, home, workplace, and hotel room in Wallet. 6 Breeze through the turnstiles by holding your iPhone or Apple Watch to the reader. Set your card to Express Mode, then just tap and hop on to ride the next train or bus. Receive detailed receipts and order tracking information in Wallet for Apple Pay purchases with participating merchants.Īdd your driver’s license or state ID to Wallet, and with just a tap of your iPhone or Apple Watch you can present your ID without handing over your device.5 The security of Face ID and Touch ID means only you can present your ID. You can even set up recurring payments like an allowance or to roommates to cover things like your share of the rent on a schedule you set, and reload your balance automatically when it’s running low. You can apply in as little as minute with no impact to your credit score.3Īpple Cash is an easy and secure way to send and receive money in Messages or Wallet.4 And because it’s a digital card that lives in Wallet, you can use it to make purchases in stores, online, or in apps with Apple Pay. You earn up to 3% unlimited Daily Cash back on every purchase every day, and it’s designed with all the privacy and security you’d expect from Apple. Pay for a ride, a pizza, or even a new sofa - with Touch ID or Face ID.Īpple Pay Later allows you to split your purchases into four equal payments over six weeks - with no interest or fees.1 Available with Apple Pay in apps and online, on iPhone or iPad.2Īpple Card is the credit card created by Apple. And it all works with iPhone or Apple Watch, so you can take less with you but always bring more.Īpple Pay is an easy, secure way to pay in stores or online. It’s where you securely keep your credit and debit cards, driver’s license or state ID, transit cards, keys, event tickets, and more - all in one place. The Wallet app lives right on your iPhone. |
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